In summary, bioinformatics analysis in the context of big data identified key roles for ten hub genes FOXM1, CDK4, TOP2A, RRM2, MYBL2, MCM2, CDC20, CCNB2, MYC and EZH2 in the development, progression, diagnosis, treatment and prognosis of GBM. This evidence concerns the gene CCNB2 and glioblastoma.