In summary, bioinformatics analysis in the context of big data identified key roles for ten hub genes FOXM1, CDK4, TOP2A, RRM2, MYBL2, MCM2, CDC20, CCNB2, MYC and EZH2 in the development, progression, diagnosis, treatment and prognosis of GBM. Here, EZH2 is linked to glioblastoma.