EZH2 (Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit) was up‐regulated in GBM, lncRNA HOTAIR, APTR and H19 could interact with EZH2, which promoted cell cycle, cell proliferation, cell invasion and tumorigenesis in GBM. The gene discussed is APTR; the disease is glioblastoma.