CASK and Encephalopathy: It is possible that with a genetic etiology of epileptic encephalopathy such as CASK mutations, the epileptic seizures may be a part of progressive encephalopathy, rather than a primary event, and hence evolve over time (encephalopathy with epilepsy) (Helbig, von Deimling, & Marsh, 2017; Khan & Al Baradie, 2012).