As we found that both IFN‐γ and 5‐AC induced transcription of SBSN in leukemic cells lines OCI‐M2 and SKM‐1, changed cytokine environment [35, 36] and epigenetic state [37] in BM of MDS patients could be putative drivers of SBSN expression. The gene discussed is IFNG; the disease is myelodysplastic syndrome.