In summary, compared with brothers of unaffected women, male siblings of women with PCOS were more insulin resistant, as well as had higher levels of uric acid, hsCRP and lower levels of 25-hydroxyvitamin D. In addition to differences in hypolipidemic effects, the impact of atorvastatin on cardiometabolic risk factors was more pronounced in subjects not having sisters with PCOS. This evidence concerns the gene INS and polycystic ovary syndrome.