In addition to the mechanistic studies which showed regulatory effects of TINCR on cancer-related pathways such as Wnt/β-catenin, ERK1/2‐SP3 and MAPK signaling pathways and important tumor suppressor genes such as P53, the presence of genomic variants within this lncRNA that influence risk of human cancer support the importance of TINCR in the carcinogenesis. The gene discussed is MAPK3; the disease is cancer.