As shown in Fig. 3, significantly higher levels of sTNFRII (P < 0.001) as well as lower levels of sCD40L (P < 0.001) and CXCL1 (P = 0.01) after one to two fractions of SBRT were noted in HCC patients who developed liver toxicity as reflected by ≥2 points decline in Child Pugh score vs. those who did not at 3 months after SBRT. The gene discussed is CD40LG; the disease is hepatocellular carcinoma.