Following only one to two of the planned six fractions of SBRT, significant differences were noted in the plasma levels of sTNFRII (P = 0.006), ANGPTL4 (P = 0.02), and sgp130 (P = 0.008) but not sEGFR (P = 0.22) amongst Child Pugh 5, 6, and 7 HCC patients (Fig. 1). The gene discussed is ANGPTL4; the disease is hepatocellular carcinoma.