When HCC patients were stratified by ALBI grade, significant differences were also detected in the plasma levels of sCD40L (P = 0.02), sTNFRII (P = 0.003), ANGPTL4 (P = 0.018), and sgp130 (P < 0.001) amongst the grade 1, 2, and 3 cohorts (Fig. 2). The gene discussed is ANGPTL4; the disease is hepatocellular carcinoma.