This is evident especially on the animal models conceived to mimic as good as possible the actual human disease, such as high-fat diet/low-dose streptozotocin type 2 diabetic Wistar albino rats in which some of the most important features of human type 2 diabetes are recognizable: hyperglycemia, insulin resistance, heightened oxidative stress, and structural and functional kidney deterioration. Here, INS is linked to type 2 diabetes mellitus.