Other studies demonstrated, aside from NF-κB inactivation and lower levels of proinflammatory cytokines, a decrease in the expression of chemokines (mainly MCP-1) and of the factors spurring sclerosis/fibrosis (especially TGF-β1), thereby warding off macrophage infiltration (curcumin [79]) and suppressing the production of collagen 4 and fibronectin, and hence ECM expansion and glomerulosclerosis (ellagic acid [37], Shen-Yan-Fang-Shuai Formula [80]). The gene discussed is FN1; the disease is glomerulosclerosis.