FN1 and glomerulosclerosis: Glomerulosclerosis is the hallmark of DN [7] and consists in proteins of extracellular matrix (ECM) (mostly collagen types I, III, and IV and fibronectin [8]) gradually and inexorably encumbering the mesangium, either by lumping together in nodular lesions or by diffusely invading and expanding the interstitial space separating the glomerular loops [9].