From 70, up to 88% of BRAF mutations are represented by V600E (valine to glutamic acid), but V600K (valine to lysine substitution) or V600D (valine to aspartic acid) and V600R (valine to arginine) are found in 5–12% and ≤ 5% of melanomas, respectively. The gene discussed is BRAF; the disease is melanoma.