BRAF and metastatic melanoma: Data published with TCGA Network, after the whole exome sequence analysis of 333 primary and/or metastatic melanoma patients, found that cutaneous melanomas could be classified into four genomic subgroups: mutant BRAF, mutant NRAS, mutant NF1, and triple-wild type (Berger et al., 2012; Furney et al., 2014; Akbani et al., 2015; Johansson et al., 2015; Hayward et al., 2017; Hintzsche et al., 2017; Lyu et al., 2017; Palmieri et al., 2018; Wilmott et al., 2019; Zhou et al., 2019).