In the nonmucinous type of colon cancer, decreased MUC2 expression was found, and expression was found to be suppressed by the transcriptional factor caudal type homeobox 2 (CDX2), which may have been caused by the high methylation modification of the promoter of the MUC2 gene (Hanski et al., 1997). This evidence concerns the gene CDX2 and malignant colon neoplasm.