They also demonstrated that although polyps from the left and right hemi-colons showed positive expression of the MUC6 gene, the positive rate of MUC6 expression in the right hemi-colons of sessile serrated adenoma and traditional serrated adenoma was significantly higher than that in the left hemi-colons of sessile serrated adenoma and traditional serrated adenoma, maybe due to the biological differences among adenomas in different parts of the colon involving the malignant transformation pathway of serrated adenomas (Gibson et al., 2011). Here, MUC6 is linked to adenoma.