BCL2 and cancer: In contrast, Bcl-2β is a splice variant of Bcl-2α (i.e., the wild-type Bcl-2), and overexpression of this Bcl-2 isoform has been shown to inhibit apoptosis and to increase chemoresistance/UV resistance in cancer cells (Schinkothe et al., 2006; Warren et al., 2016).