CD96 and central nervous system cancer: To further elucidate the immune function of CD96 in glioma, on the basis of the 1,540 genes reported to be associated with the immune response which were downloaded form the AmiGO 2 website7 (Li G. et al., 2017), we selected the 362 and 354 genes most relevant to CD96 (Spearman |rho| > 0.3) in the CCGA and TCGA cohorts (Supplementary Table S2) for heatmap drawing (Liu et al., 2019).