CD80 and neoplasm: Additionally, under the action of costimulatory signals (“second” signal, including the coaction of B7-type CD80/86 receptor on DC with CD28 on T lymphocytes) and cytokines (“third” signal, such as IL-2 and IL-12), activated T lymphocytes travel to the (pre)neoplastic tissue through the bloodstream, and followed by specific destruction of (pre)neoplastic cells expressing the respective tumor-specific antigens.