In addition to the inhibition of TLR signaling and NF-κB signaling pathway mentioned above, auranofin also reduces TNF-α synthesis and secretion, decreases STAT-3 transcription activity as well as inhibits angiogenesis (Kim et al., 2007; Han et al., 2008a), which are related to tumor growth and development. This evidence concerns the gene NFKB1 and neoplasm.