The initiation of ICD is based on several different molecular mechanisms in the dying tumor cells, mainly by endoplasmic reticulum (ER) stress- and autophagy-mediated release of DAMP molecules, including the protein chaperones calreticulin (CRT), the nucleotide ATP, DNA damage sensitizer HMGB1, CXCL10 as well as HSP70/90 (Terenzi et al., 2016). The gene discussed is CALR; the disease is neoplasm.