HIF1A and neoplasm: While in solid tumors hypoxia is postulated to ensure as a result of reduced oxygen availability due to dysfunctional angiogenesis, recent findings indicate that heightened mitochondrial activity largely contributes to tumor hypoxia and HIF-1α stabilization; further, a series of known OxPhos inhibitors, including IACS-010759 used here, were initially developed as HIF-1α inhibitors (47–49).