In chordoma cells, loss of BRACHYURY resulted in a significant decrease of Snail and Slug (31, 49), and the upregulation of Snail and Slug by FGF2 was blocked by BRACHYURY knockdown, suggesting that BRACHYURY plays a critical role in the direct regulation of Snail and Slug expressions and EMT process of chordoma (31). Here, SNAI1 is linked to chordoma.