Although the specific role of BRACHYURY/BRACHYURY on the tumorigenesis and progression of prostate cancer has been recognized, more details need to be further investigated and unveiled, for instance, the mechanism of BRACHYURY involved in NEtD, the biological significance of BRACHYURY binding with the regulatory elements of the marker genes (AMACR, AR) of prostate cancer. Here, AMACR is linked to Familial prostate cancer.