In general, good consistency of CORO1C and TMPRSS4's prognostic values for overall survival outcome has been observed among three data sets, robustly indicating that CORO1C is a risk factor in bladder cancer development while TMPRSS4 is a protective factor, and as hub genes, their relationships with clinicopathological features are in accord with the purple and light green modular characterizations that have been described by WGCNA analysis (Figure 3A). This evidence concerns the gene TMPRSS4 and urinary bladder carcinoma.