Previous studies have reported that the expression of miRNAs in drug-resistant cells of various tissues and organs was negatively associated with the expression of ABCB1 (49, 50), suggesting that the expression of some miRNAs in HCC was likely related to the alterations of MDR-1/P-gp expression and change of MDR phenotype. This evidence concerns the gene ABCB1 and hepatocellular carcinoma.