PGP and hepatocellular carcinoma: Chen et al. (53) have demonstrated that overexpression of miR-27a in the BEL/5-FU cells (multidrug-resistant cell line of liver cancer) reduced the expressions of MDR1/P-gp and β-catenin but enhanced the sensitivity of these cells to 5-FU-induced apoptosis, suggesting that miR-27a may be a new therapeutic target for HCC.