EPAS1 and hepatocellular carcinoma: Similar studies have been reported on the correlation between lncRNA MALAT1 and HIF α subunits, in HCC cells, confirming at least two miR-216b binding sites in lncRNA MALAT1, suggesting a possible role of HIF-2α-MALAT1-miR-216b axis in the regulation of MDR in HCC (30).