Herein it is important to highlight that the interaction between PD-L1 and HPV oncoproteins could be specific to only certain types of high-risk HPVs or coinfection with more than one type since more than 96% of human cervical cancers are positive for HPVs, while around 40% of these cancer cases overexpress PD-L1, as reported by Meng et al. (39) and Feng et al. (43). Here, CD274 is linked to cancer.