HMOX1 and myocardial infarction: As shown in Figure 5(a), as expected, the treatment with WAAE and WTAAE significantly increased the mRNA expression levels of Nrf2 (P < 0.05) and AAEs significantly increased the levels of HO-1 and GST (P < 0.05 or P < 0.01) in heart tissue of ISO-induced MI rats, playing a significant antioxidant damage effect by upregulating and activating the Nrf2-ARE pathway.