KMT2D and extranodal nasal NK/T cell lymphoma: Zhao et al. confirmed that the most frequently mutated genes in NKTCL were the RNA helicase gene DDX3X, tumor suppressors (TP53 and MGA), JAK-STAT pathway molecules (STAT3 and STAT5b) and epigenetic modifiers (MLL2, ARID1A, EP300 and ASXL3) [36, 37].