RPS6KB1 and infection: Most importantly, infection with NDI1 resulted in partly rescuing MEDICA suppression of ErbB1, ErbB2, and ErbB3, and their downstream target phospho-Akt(Thr308, Ser473), as well as in rescuing MEDICA inhibition of mTORC1 downstream substrates phospho-S6K1(Thr389), phospho-S6(Ser240/244), and phospho-4EBP(Thr37/46) (Fig. 6a–c).