Similarly to the atopic/allergic status, the response to parasitic infections is also associated with the induction of strong Th2 immune responses, leading to eosinophilia, elevated Th2 cytokines and increased serum IgE (e.g. in a cohort of patients with Ascaris infection, total IgE levels reached 13,000 kU/L) [71, 72]. This evidence concerns the gene IGHE and parasitic infectious disease.