For the total positive rate of IRS-1 expression, a significantly increased level was observed in human HCC (Figure 3), compared with those in paracancerous tissues (PCT) (41/100, 41.0% Vs. 17/100, 17.0%, P < 0.001), LC (41/100, 41.0% Vs. 3/20, 15.0%, P = 0.028), and CH tissues (CHT) (41/100, 41.0% Vs. 2/20, 10.0%, P = 0.008). This evidence concerns the gene IRS1 and hepatocellular carcinoma.