To predict the prognosis of AFP-negative HCC patients, parameters recognized as significant in the multivariate analysis were used to form the GGT-based prognostic score (GBPS) as follows: GBPS = TBIL (≤17.2 = 0; >17.2 = 1) + GGT (≤37.2 = 0; 37.2‐102.8 = 1; ≥102.8 = 2) + ALBI (grade 1 = 0; grade 2 = 1) + cirrhosis (absent = 0; present = 1) + tumor number (≤1 = 0; >1 = 2) + MVI (absent = 0; present = 2). This evidence concerns the gene AFP and neoplasm.