JAK/STAT3 signaling is a well-identified oncogenic pathway that plays a pivotal role in various cellular biological activities important for carcinogenesis, including cell survival, cell cycle, and angiogenesis in multiple cancers [39], and the activation of the JAK/STAT3 pathway in CRC has been largely indicated [32, 40, 41]. This evidence concerns the gene STAT3 and colorectal carcinoma.