CD4 and melanoma: Excessive proliferation of melanoma cells activates stromal and melanoma-residing immune cells (macrophages, DCs, NK, and NKT cells) which produce a large amount of proinflammatory chemokines and cytokines (TNF-α, IL-12, IFN-γ, and IL-17) that facilitate the massive influx of circulating leucocytes in the tumors and enable generation and expansion of tumorotoxic CD8+CTLs, CD4+Th1, and Th17 cells in the peripheral lymph organs [28].