MSC1 cells inhibited production of immunosuppressive cytokines (IL-10 and TGF-β) in tumor-infiltrating immune cells and promoted generation and influx of cytotoxic, FasL, perforin, and granzyme B-expressing and IFN-γ- and IL-17-producing CTLs and NK cells in the tumors of B16F10+MSC1d-treated mice which resulted in reduced melanoma growth and progression (Figure 2). Here, PRF1 is linked to melanoma.