TNF and melanoma: Since MSCs adopt proinflammatory (MSC1) or immunosuppressive (MSC2) phenotype in response to the inflammatory and immunosuppressive cytokines to which they are exposed [18], we analyzed and compared the concentration of inflammatory (TNF-α, IFN-γ) and immunosuppressive cytokines (IL-10, TGF-β) in plasma samples of melanoma-bearing mice at the time of MSC administration.