Through lymphocyte recirculation mechanisms, CD4+/CD25+/FoxP3+ Tregs produced in the gastric mucosa travel to other lymphoid tissues in distant organs to exert a systemic immunoregulatory effect that influences the pathogenesis of various autoimmune and allergic diseases, such as IBD, eczema, and asthma. This evidence concerns the gene FOXP3 and Eczematoid dermatitis.