Prompted by an earlier result linking the expression of PPARα to that of PKC in rat liver [229], Blanquart et al. demonstrated that the phosphorylation of PPARα at Ser179 and/or Ser230 by PKC increased both basal and ligand-induced transcription of target genes such as carnitine palmitoyltransferase 1 (CPT1) and PPARA in a human liver cancer cell line [227]. The gene discussed is PPARA; the disease is liver cancer.