Transcriptome analysis of murine lungs from early-stage infection (14 h) by R. delemar showed a significant enrichment of genes that are known to be targets of epidermal growth factor receptor (EGFR) signaling suggesting that the EGFR pathway was activated in response to R. delemar. Subsequent in vitro and in vivo infection experiments demonstrated that EGFR was indeed phosphorylated (activated) upon Mucorales infection and governed the ability of Mucorales to invade and damage host cells. Here, EGFR is linked to infection.