APOB and autosomal dominant disease: FH is an autosomal dominant disease associated with pathogenic variants in the low density lipoprotein receptor gene (LDLR), the apolipoprotein B gene (APOB), or the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) (Brown and Goldstein, 1986; Rader et al., 2003).