FSTL1 and neoplasm: It is noteworthy that FSTL1 is significantly related to tumor metastasis, and up or down regulation of FSTL1 in different cancers greatly induces their migratory and invasive capacity, leading to tumor dissemination (Kudo-Saito et al., 2013; Ni et al., 2018; Chiou et al., 2019).