Based on insight into immunopathogenesis and pathology during COVID-19, potential susceptibility genes may be involved in mechanisms of immune dysregulation, auto-inflammation or autoimmunity, thus involving the gain-of-function or loss of inhibition of various genes and pathways in cytokine and TLR signaling cascades, especially those affecting IL-1 and IL-6 synthesis and production (48–50). This evidence concerns the gene IL1B and COVID-19.