Although IL-33 is strongly implicated in inducing eosinophilic inflammation in anti-parasite or allergic type 2 immune responses (21, 30), the cytokine has also shown protective effects in models of colitis (31), graft-vs.-host disease (32), autoimmunity (33), obesity (34), wound healing and tissue restoration (35, 36). This evidence concerns the gene IL33 and Autoimmunity.