IGHE and allergic disease: The absence of IL-4 hyperproduction when using an adjuvant vaccine explains the results of clinical studies in which literature analysis shows that when vaccination against influenza with a subunit vaccine with an Azoximer bromide adjuvant in children with allergic diseases, there was a significant decrease in the content of IgM and total IgE in the blood serum after 1 month and there was a tendency to increase endogenous IFN-γ and IL-12 (49).