The inability to mount an IgA-mediated response against the pneumococcal polysaccharide antigens or the inability to maintain the antibody response over time was associated to a greater frequency of URTI and LRTI exacerbations due to a variety of pathogens (24, 25) during FU, to chronic lung damage and to a greater risk to develop non-infectious complications, autoimmunity and chronic diarrhea during the observation period. Here, CD79A is linked to Autoimmunity.