Interestingly, both epithelial cell–specific IκB-ζ KO mice and epithelial cell–specific STAT3 KO mice show SS-like phenotypes, such as lymphocyte-infiltrating periocular dermatitis, dacryoadenitis, conjunctivitis, autoantibodies against SSA and SSB, and impaired tear secretion, suggesting a role of dysregulated homeostasis of epithelial cells in the pathogenesis of the disease (109). This evidence concerns the gene NFKBIZ and synovial sarcoma.