This glandular epithelial cell apoptosis has been observed in many mouse models of SS, for example, in NOD-derived strains (145–147), Ar KO mice (37, 77), RbAp48-tg mice (80), NFS/sld mice (60, 61), STAT3 KO mice (109), and TSP-1 KO mice (92). The gene discussed is STAT3; the disease is synovial sarcoma.