TNFSF13B and nephritis: BAFF transgenic C57BL/6 (BAFF-tg) mice overexpressing BAFF develop systemic autoimmune symptoms characterized by B cell hyper-proliferation, high levels of rheumatoid factor and anti-DNA antibody production, SLE-like nephritis, lymphocyte infiltration in the lacrimal glands, sialadenitis, and impaired salivary secretion (104).