Moreover, the RbAp48-tg mice developed autoimmune exocrinopathy resembling Sjögren's syndrome, including lymphocytic infiltration in the exocrine glands; the impairment of saliva and tear secretion; the ectopic expression of MHC II molecules on glandular epithelial cells; and the production of autoantibodies against SSA/Ro, SSB/La, and 120 kD α-fodrin (81). Here, CALR is linked to Sjogren syndrome.