To date, C57/BL6 mice, immunocompromised IFNAR −/− C57/BL6 mice, and aged-ferrets were used for SFTS study, among which, IFNAR −/− C57/BL6 mice and aged-ferrets are lethal SFTSV infection models that exhibit SFTS clinical features observed in human patients. The gene discussed is IFNAR1; the disease is infection.