The present finding that recurrent CN-gains at nsv1177513 and esv2730987 were enriched in PMDD subjects thus expanded further the spectrum of neuropsychiatric disorders associated with GABRB2 beyond SCZ (3, 8), bipolar disorder (10), and heroin addiction (20), and provided the first known instance of PMDD association with a gene expressed in the central nervous system. This evidence concerns the gene GABRB2 and bipolar disorder.