INS and type 2 diabetes mellitus: In addition, Kv7.1 channels in the pancreatic ß-cells contribute to the regulation of insulin secretion, and loss of function mutations in the KCNQ1 gene leads to impaired ß-cell insulin secretion, which is associated with type 2 diabetes (Ullrich et al., 2005; Unoki et al., 2008; Yasuda et al., 2008; Yamagata et al., 2011; Liu et al., 2014; Torekov et al., 2014; Min Lee et al., 2017; Zhang et al., 2020).