It has further been found that parthenolide directly binds to the ribosome protein RPL10, blocks the protein synthesis of TCF4/LEF1, and decreases their protein levels, therefore inhibiting β-catenin/TCF/LEF-mediated gene transcription and the proliferation of colon cancer cells, without affecting the stability and subcellular distribution of β-catenin (Zhu et al., 2018). The gene discussed is HNF4A; the disease is colonic neoplasm.