HNF4A and colonic neoplasm: The well-known chemopreventive agent curcumin, a dietary polyphenol from the ginger family Curcuma longa has been shown to down-regulate the nuclear level of β-catenin and disrupt the binding of β-catenin/TCF/LEF to the promoter DNA, thus blocking β-catenin-dependent gene expression, inhibiting cell viability, migration, and invasion, and inducing cell cycle arrest at the G2/M phase and apoptosis in osteosarcoma and colon cancer cells (Jaiswal et al., 2002; Leow et al., 2010).