The UPR related proteins, such as protein kinaseR–like ER kinase (PERK), inositol-requiring enzyme 1a (IRE1α), binding immunoglobulin protein (BiP/GRP78) and transcription factor C/EBP homologous protein (CHOP) could be suppressed to mitigate ER stress condition for cancer survival including GBM (Le Reste et al., 2016; Penaranda Fajardo et al., 2016; Madden et al., 2019). Here, HSPA5 is linked to glioblastoma.