PROM1 and central nervous system cancer: CD133 is a pentaspan transmembrane protein and was commonly used as a glioblastoma stem cells (GSCs) biomarker, it has been showed that CD133 positive (CD133+) glioblastoma cells contributes to glioma radioresistance and tumor progress through preferential checkpoint response and DNA repair (Beier et al., 2007; Norollahi et al., 2019).