HSP90AB1 and glioblastoma: As a preliminary study demonstrated that Hsp90 inhibitor could enhance the radiotherapy in a variety of human cancer cell lines, including GBM (Piper and Millson, 2011), we here explored the anti-neoplastic efficacy and mechanisms of NXD30001 as a monotherapy or in combination with radiation in GSCs and GBM orthotopic animal model.