The observed negative relationship between the expression of several Pcdhs and the nuclear accumulation of β-catenin contradicts findings describing increased Wnt signaling and TCF/LEF activity due to nuclear accumulation of β-catenin with PCDH11Y overexpression in human prostate cancer cells (LNCaP) (Yang et al., 2005). The gene discussed is PCDH11Y; the disease is prostate carcinoma.