For example, in vitro studies suggested that [18F]-MK6240 and [18F]-JNJ-067 bound with neurofibrillary tangle (NFT) (Hostetler et al., 2016), whereas [18F]-RO948 bound to both NFT and neuropil threads (Honer et al., 2018), whereas [18F]-JNJ64349311 interacted with PHF-tau and neuropil threads (Declercq et al., 2017). The gene discussed is MAPT; the disease is Neurofibrillary tangles.