MAPT and Alzheimer disease: The presence of severe tau cytoskeletal pathology in the thalamic nuclei with limbic connectivity likely contributed to impaired neural processing in limbic circuits, manifesting in certain cardinal symptoms of AD (Braak and Braak, 1991a, b; Rub et al., 2000, 2002; Blennow et al., 2006; Lace et al., 2007; Grinberg et al., 2009; Braak and Del Trecidi, 2015).