Our findings of [18F]-APN-1607 had relatively lower SUVR in the present study [temporal lobe: 1.64 (±0.50), MMSE = 17.0 (±7.6), Cohen d = 2.1] comparing to [18F]RO-948 and [18F]-PI2620, which might arise from the relatively rough ROI; however, the relatively high Cohen d value indicated that [18F]-APN-1607 was a highly sensitive tracer for detecting tau aggregates in AD. Here, MAPT is linked to Alzheimer disease.