Based on the obtained results, the ICC tissues in the FOS, IGF1R, and IGF2 high expression groups were significantly enriched in “the TGF-β signaling pathway”, “the hedgehog signaling pathway”, and “the retinol metabolism”, respectively (Fig. 7a–c); the ICC tissues in the FOXO1 and NTF3 high expression groups were notably enriched on the “type 2 diabetes mellitus” (Fig. 7d, e). Here, IGF2 is linked to intrahepatic cholangiocarcinoma.