IL1B and neoplasm: In addition, IL-1β was previously shown to be significantly correlated with clinical outcome in oesophageal SCC, whereby patients with IL-1β positive tumours had a poor response to treatment compared to patients with IL-1β negative tumours, the suggested underlying mechanism of this difference in tumour response was increased epithelial–mesenchymal transition aggressive tumour growth in IL-1β-positive tumours37.