IL3 and fibrosarcoma: Elevated gene expression of IL-3 in fibrosarcoma xenografts (FSA-JmIL-3 tumours) was associated with enhanced response to radiation compared to parental tumours, where FSA-JmIL-3 tumours were associated with increased lymphocyte infiltration and elicited immune responses41, suggesting that the enhanced secretion of IL-3 following pyrazinib (P3) treatment is a positive effect of this small molecule compound.