In summary, serum IL-32 concentration is higher in patients with stable COPD than in healthy individuals, and increased IL-32 is positively correlated with GOLD grade, mMRC score and clinical medical history of patients but negatively with FEV1/FVC and FEV1% predicted, suggesting that IL-32 is involved in the chronic disease process of COPD and changes in IL-32 can be used to assess the severity of COPD and contributes to the diagnosis of COPD. This evidence concerns the gene IL32 and chronic obstructive pulmonary disease.