CD274 and neoplasm: In KEYNOTE-189,68 a Phase 3 double-blind, randomised placebo-controlled trial of patients with metastatic non-squamous NSCLC and any level of tumour PD-L1 expression, first-line pembrolizumab plus platinum-based chemotherapy (cisplatin or carboplatin) and pemetrexed was superior to platinum-based chemotherapy and pemetrexed in terms of OS (overall HR 0.49, 95% CI 0.38–0.64) and PFS (overall HR 0.52, 95% CI 0.43–0.64).