Radiation-induced immunogenic cell death induces the release of tumour antigens, dendritic cell maturation, augmentation of T-cell priming, upregulation of MHC-I and PD-L1 expression, and upregulation of the levels of cytokines and chemokines83–87—consequently, interest in combining radiotherapy with immunotherapy agents to improve antitumour immunity and responses has increased. This evidence concerns the gene CD274 and neoplasm.