CD274 and neoplasm: In KEYNOTE-407,72,73 a Phase 3 double-blind randomised placebo-controlled trial of patients with metastatic squamous NSCLC and any level of tumour cell PD-L1 expression, first-line treatment with pembrolizumab plus carboplatin plus either paclitaxel or nab-paclitaxel was superior to carboplatin plus taxane alone in terms of OS (17.1 versus 11.6 months; HR 0.71, 95% CI 0.58–0.88) and PFS (8.0 versus 5.1 months; HR 0.57, 95% CI 0.47–0.69).