CD274 and neoplasm: No age-specific data on toxicity are available from these three trials but the overall incidence of TRAEs of grades 3–5 varied between 13 and 31% with pembrolizumab versus 35 and 53% with chemotherapy.45,47,48 A 2019 pooled analysis of the above-mentioned Phase 3 trials focused on the efficacy and safety in patients aged 75 years or above and confirmed an OS benefit of pembrolizumab (tumour PD-L1 expression of either ≥1 or ≥50%) versus chemotherapy, with a favourable toxicity profile, similar to their younger counterparts.49,50