CD274 and non-small cell lung carcinoma: This anti-PD-L1 monoclonal antibody was explored as monotherapy versus docetaxel in the Phase 3 OAK trial in pretreated NSCLC patients regardless of their PD-L1 expression.60 The median OS was 13.8 months on atezolizumab compared with 9.6 months on docetaxel (HR 0.73, 95% CI 0.62–0.87; P = 0.0003).