The first part, which has been published, had two independent primary endpoints: PFS with nivolumab plus ipilimumab versus chemotherapy in patients with a high tumour mutational burden (≥10 mutations per megabase);79 and OS with nivolumab plus ipilimumab versus chemotherapy in patients with a tumour PD-L1 expression level of 1% or more.80 For other hierarchical endpoints, the trial included a group with PD-L1 expression below 1% and also treatment arms with nivolumab or nivolumab plus chemotherapy. Here, CD274 is linked to neoplasm.