(Italian Group of Cholangiocarcinoma) involving 940 Italian patients with aBTC captures ECOG, prior resection, tumour grading, baseline carcinoembryonic antigen and carbohydrate antigen 19.9 as factors that are independently associated with OS.18 Further studies incorporating putative molecular prognostic factors, such as the fibroblast growth factor receptor (FGFR)-2 fusions, are needed to identify genomic prognostic variables that might help to identify prognosis and predict treatment outcomes. This evidence concerns the gene FGFR2 and cholangiocarcinoma.