Hypothyroidism has 4 genes (HLA-DPA1, HLA-DQB1, HLA-DQA1, and HLA-DPB1, where two have 5% of predictor variance each and two have 1% each) out of its top 17 genes included among the 641 potentially problematic genes, while 8% is the highest value of predictor variance accounted for by a single gene. The gene discussed is HLA-DQB1; the disease is hypothyroidism.