Type-1 diabetes has 12 genes (HSPA1L, HLA-DRB1, BTNL2, HLA-DQB1, HLA-DQB2, NEU1, HLA-DOA, HLA-DQA1, HLA-DRA, HSPA1B, C6orf48, LSM2) out of its top 25 genes among the 641 potentially problematic genes. Here, HLA-DQB1 is linked to type 1 diabetes mellitus.