We observed that, compared with matched non-diabetic/non-hypertensive donors (age: 58.12 ± 2.6 years; and, BMI: 25.84 ± 0.99), the presence of type 1 diabetes/hypertension (age: 58.12 ± 2.6 years; and, BMI: 26.97 ± 0.90) associates with an increase in the expression levels of MD2 but not TLR4 (Fig. 2C). Here, TLR4 is linked to hypertensive disorder.