Briefly, we clarified that high expression of circTADA2A suppressed fibroblasts activation by upregulating Cav1 via targeting miR-526b, reduced fibroblasts proliferation by upregulating Cav2 via targeting miR-203, thus decreasing ECM deposition and alleviating IPF. The gene discussed is CAV1; the disease is idiopathic pulmonary fibrosis.